SC-514, IKKbeta inhibitor (CAS 354812-17-2) (ab144415) (2024)

Overview

• Product name

  SC-514, IKKbeta inhibitor

• Description

  Selective, ATP-competitive, irreversible IKKβ inhibitor

• Purity

  > 98%

• CAS Number

  354812-17-2

• Chemical structure

  

Properties

• Chemical name

  3-Amino-5-thiophen-3-ylthiophene-2-carboxamide

• Molecular weight

  224.30

• Molecular formula

  C₉H₈N₂OS₂

• PubChem identifier

  2807869

• Storage instructions

  Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

• Solubility overview

  Soluble in ethanol to 10 mM and in DMSO to 100 mM

• Handling

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Toxic, refer to SDS for further information.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES

  C1=CSC=C1C2=CC(=C(S2)C(=O)N)N

• Source

  Synthetic

• Research areas

  • Cell Biology
  • Apoptosis
  • Intracellular
  • NFkB
  • IKK

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • Other Kinases

  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • NFkB Pathway

  • Cardiovascular
  • Atherosclerosis
  • Vascular Inflammation
  • Inflammatory mediators

  • Immunology
  • Innate Immunity
  • TLR Signaling

  • Biochemicals
  • Product Range
  • New

  • Biochemicals
  • Chemical Type
  • Biochemicals

  • Biochemicals
  • Pharmacology
  • Signaling
  • Signal transduction

  • Biochemicals
  • Pharmacology
  • Enzymes
  • Kinase
  • IKK

  • Cancer
  • Cell Death
  • Apoptosis
  • Apoptosis Markers
  • NFkB
  • IKK

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

• SDS download

  Country/Region

  Language

  

• Datasheet download

  Download

ab144415 has been referenced in 2 publications.

• Pan D et al. Increasing toll-like receptor 2 on astrocytes induced by Schwann cell-derived exosomes promotes recovery by inhibiting CSPGs deposition after spinal cord injury. J Neuroinflammation 18:172 (2021). PubMed: 34372877
• Cursano S et al. A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome. Mol Psychiatry N/A:N/A (2020). PubMed: 32051550